Miguel Servet University Hospital, Spain
Javier Obis is an Ophthalmologist, has expertise in ophthalmological alterations related to Parkinson’s disease. He has published several articles in PubMed about retinal and choroid alterations measured with OCT in neurological diseases, especially in PD. He has researches on visual alterations related with PD and other neurological diseases. He is currently working on his doctoral thesis, which studies the retinal and choroid thickness alterations that appear in patients with PD and also the visual alterations that these patients suffer.
Parkinson’s Disease (PD) is a neurodegenerative process that causes a selective loss of dopaminergic neurons, mainly in the basal ganglia. It also affects the intra retinal dopaminergic circuitry. Optical Coherence Tomography (OCT) is a non-invasive imaging technique which is used in ophthalmology to evaluate the layers of the retina and choroid (the vascular layer that nourishes the retinal
cells). Since 2004, several studies have proved changes on various retinal layers in PD using OCT; however, there are discrepancies among their results. Some of them have correlated retinal thickness with the severity or duration of the disease, demonstrating that OCT measurements may be an innocuous and easy biomarker for PD progression. Other studies have demonstrated visual dysfunctions since early phases of the disease. Lastly, the most recent studies that use Swept Source OCT technology, have found choroidal thickness increase in PD patients.