Ahed J Alkhatib
Jordan University of Science and Technology, Jordan
Title: The role of natural antioxidants in declining memory defects in Alzheimer’s disease
Biography:
Ahed J Alkhatib is currently working as a researcher in Department of Forensic Science and Toxicology, Jordan University of Sciences and Technology, Jordon from 2011 to till date. He completed his PhD in Campbell University, medical technology, North Carolina, USA from 2008 to 2011.
Abstract:
Alzheimer’s disease is a disease associated with neurodegenerative nature. We look for this disease in depth and think that functional alterations in white matter precede the clinical onset of Alzheimer’s disease. As it were, it involves cerebrum maturing that happen by years (might be 5 years) before Alzheimer's infection had been created. This period is characterized by depression, which partly may be due to memory declining episodes. It was interestingly found that patients with diabetes are more likely to develop Alzheimer’s disease. We have found using experimental animal models that rats with diabetes exhibited functional abnormalities in white matter. In other words, we found two biomarkers with different expressions, the expression of inducible Nitric Oxide Synthase (iNOS) was highly expressed in white matter of diabetic rats compared with expression of iNOS in grey matter of the same group (p=0.000). On the other hand, the expression of heat shock protein 70 (Hsp70) exhibited different biological reactivity in which its expression was signifi cantly decreased in white matter compared with that in grey matter of the same group (p=0.000).