Alexandria University, Egypt
Title: Serum levels of resistin and its relationship with some pro-infl ammatory cytokines in a cohort of Egyptian patients with Alzheimerâ€™s disease
Marwa A. Saad born in October 26th 1974,Egyptian , BMCH; Faculty of Medicine, Alexandria University, Egypt, Oct 1998 graduated with Excellent with honor” .Master degree of Internal Medicine; Faculty of Medicine, Alexandria University, Egypt, 2003. Graduation Grade: very good.The Master Degree thesis was:“Effect of Age on Some Hemorheological Parameters.” Thesis was accepted and graded as Excellent.Doctorate Degree in Internal Medicine; Faculty of Medicine, Alexandria University, Egypt. 2009.The Doctorate Degree thesis was:“Ischemic Stroke in relation to Interleukin-6, Interleukin-13, and certain markers of inflammation in elderly patients”
Inflammation may play an important role in Alzheimer disease (AD) pathogenesis. Resistin has hallmark regulatory functions in the inflammatory states. The aim of this study was to determine whether plasma resistin levels would be useful in the diagnosis of patients with AD and to investigate the relationships between resistin and other inflammatory markers namely IL-6, TNF-α, and CRP. 95 AD patients and 35 sex and age matched healthy subjects were included in the present study. Subjects with the following conditions were excluded from the study; DM, hypertension, liver or renal failure, ischemic heart disease, congestive heart failure, stroke, subjects with BMI over 25, thyroid disorders, active infection or other inflammatory diseases, chronic use of anti-inflammatory drugs. The diagnosis of AD was determined based on the Diagnostic and Statistical Manual of Mental Disorders 4th edition, text revision (DSM-IV-TR) criteria and MMSE. Serum resistin, IL-6, TNF-α, and CRP were measured for all participants. Serum levels of resistin, IL-6, CRP, and TNF-α were significantly higher in patients with AD than healthy controls. The resistin levels were positively correlated with the levels of IL-6, CRP, and TNF-α. MMSE was negatively correlated with IL-6, CRP, and TNF-α, whereas the correlation is only significant with CRP. A high statistically negative correlation was found between MMSE and resistin levels. We concluded that serum resistin may be linked to neuro-inflammtion of AD. Further studies with large patients’ number are needed in order to investigate a novel therapy for reversing or arresting the disease in the case of AD.